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Male bodybuilders running a retatrutide cut without testosterone support may experience declining testosterone levels as their body fat drops and caloric intake decreases, compounding the risk of muscle loss

GLP-1 receptor agonists function by mimicking a hormone that targets areas of the brain involved in appetite regulation

Retention is where the unit economics get healthy, and GLP-1 adherence is genuinely hard: side effects, plateaus, cost, and titration confusion all drive drop-off

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After 4 to 6 weeks, the dose can be increased to 1.0 mg if tolerated well